99% CAS 15307-79-6 Diclofenac Sodium details
Diclofenac Sodium Description
Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces the metabolite 4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble
amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.
Diclofenac Sodium Specification
Characteristics
| White crystalline powder |
Solubility:
| Sparingly soluble in water, freely soluble in methanol, ethanol(96%);slightly soluble in acetone; practically insoluble in ether., |
Melting point | 275-277 |
Related Substances: | Single impurity max 0.2% total impurity max 0.5% |
Heavy metal:
| Max 10ppm |
Loss on drying
| Max 0.5% |
Assay: | 99.0-101.0% |
Diclofenac Sodium Picture
Diclofenac Sodium Function
1. Relieve rheumatoid arthritis and osteoarthritis. Acute exacerbation of osteoarthritis of the spine, gouty arthritis, rheumatoid arthritis, or persistent joint swelling and pain;
2. kinds of soft tissue, such as rheumatic pain, shoulder pain, tenosynovitis, bursitis and myalgia after exercise injury pain;
3, acute mild and moderate pain, such as: surgery, trauma, strain and other pain;
4, primary dysmenorrhea, toothache, headache, etc.
Diclofenac Sodium package and shipping
[Storage] Stored in a clean, cool and dry area; keep away from strong, direct light.
[Shelf Life] 2 years when properly stored.
[Packing]
Inner double plastic bags--25kg/Fiber drum (35*35*53cm, GW: 28kg, NW: 25kg, 0.06CBM);
Inner double plastic bags--5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg);
Inner double plastic bags--1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
[Delivery] 5 working days after payment.
Shipping
1. Preferentially DHL or FedEx for quantity less than 50KG; Air shipping for 100KG above;
Sea shipping for quantity over 500KG.
Company information
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